It is used once daily to help breathing symptoms and reduce the number of asthma or COPD flare-ups over the long-term. 2018;378(18):1671-1680. Here we look at how Trelegy Ellipta and Breo Ellipta are alike and different. Trelegy Ellipta is NOT a fast-acting rescue medicine to be used during a sudden breathing attack in COPD or asthma. Common side effects when Trelegy is used for COPD include: upper respiratory tract infection, pneumonia, bronchitis, oral candidiasis (thrush), headache, back pain, joint pain, influenza (flu), sinusitis, sore throat, runny nose, altered taste, constipation, urinary tract infection, diarrhea, gastroenteritis, mouth/throat pain, cough, and voice hoarseness. Youll usually take two puffs of the medication twice a day. Vilanterol is also minimally absorbed orally. Trelegy Ellipta comes as an inhaler. It is usually oxidized via hydroxylation or O-dealkylation and then conjugated via glucuronidation to produce metabolites. Researchers measured peoples forced expiratory volume in 1 second (FEV1), which is the amount of air you can force out of your lungs in 1 second. Primary treatment of status asthmaticus or other acute episodes of COPD or asthma where intensive measures are required. Trelegy Ellipta was studied in over 10,000 patients with symptomatic chronic obstructive pulmonary disease (COPD) and a history of prior exacerbations (flare-ups). How long does it take for Trelegy to work? Fluticasone furoate is an inhaled corticosteroid that works by decreasing inflammation, which is a main component of COPD and asthma symptoms. The drug isnt meant to be used for sudden breathing problems caused by asthma. However, because there are three different drugs in Trelegy Ellipta, taking too much Trelegy Ellipta would mean taking too much of all three drugs. Then, take your next dose at your usual time. After oral administration, 70% of the drug was recovered in urine and 30% was recovered in feces. Use your Trelegy Ellipta inhaler at the same time every day. For information about this, see the Trelegy Ellipta use with other drugs section below. Higher FEV1s show better lung function, while lower FEV1s show poorer lung function. Each inhaler has two foil strips inside it that contain blisters of the medication. If your potassium level gets too low, you can have heart problems such as an irregular heart rhythm (a heartbeat thats too fast, too slow, or uneven). The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. Rinse your mouth with water without swallowing after use to help prevent thrush (a yeast infection in your mouth and throat area). Trelegy Ellipta is indicated for use in adults with either chronic obstructive pulmonary disease (COPD) or asthma. Revision date: October 4, 2022. prednisone, Symbicort, Breo Ellipta, Xopenex, Anoro Ellipta, Atrovent, Dulera, Stiolto Respimat, Nucala. Youll take one inhalation (puff) of the medication once a day. In the trials, Trelegy Ellipta was compared with two of its three drugs: fluticasone and vilanterol. Brand-name medications usually cost more than generics. However, beta-blockers can block the effects of Trelegy Ellipta and cause the medication to not work properly. After an intravenous dose, 58% is excreted in the feces and 22% is excreted in the urine. With asthma, you may have symptoms such as: Its important to note that Trelegy Ellipta is meant to be used over time to control asthma symptoms. Trelegy Ellipta is meant to be used as a long-term treatment. It combines an inhaled corticosteroid (ICS), a long-acting muscarinic antagonist (LAMA) and long-acting beta2-adrenergic agonist (LABA). A one-year long clinical study with over 10,000 patients showed that Trelegy was more effective for reducing moderate-to-severe flare-ups (exacerbations) and improving lung function compared to using Breo 100 (an ICS/LABA) or Anora (a LAMA/LABA). urinary tract infection *. Only remove the inhaler from the unopened tray when ready to use. There are currently no generic forms of either drug. Steroids can increase your level of cortisol, which is a hormone that has effects on your metabolism. Its Cmax occurs about 5 to 15 minutes post-dose. Note: Trelegy Ellipta is meant to be used over time to control asthma symptoms. The drug isnt meant to be used for sudden breathing problems caused by COPD. Urine tests can detect cannabis in the urine for approximately 3-30 days after use. They can review any possible drug interactions for you. This is an inhaler that dispenses the drug as a spray, which you breathe into your lungs. Trelegy Ellipta may not be right for you if you have certain medical conditions or other factors affecting your health. That means with a half-life of 5 days, it will likely take 27.5 days-almost a whole month-for the body to clear this drug. Can you just stop taking Trulicity? Its half-life is 11 hours. Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. If you have headaches that are bothersome to you during your Trelegy Ellipta treatment, talk with your doctor. The medication is in a powder form that you breathe into your lungs. In clinical studies, back pain occurred in 2% to 4%* of people who took Trelegy Ellipta. The drugs are fluticasone, umeclidinium, and vilanterol. The maximum recommended dosage is 1 inhalation of TRELEGY ELLIPTA 200/62.5/25 mcg once daily. Below are examples of these side effects. Use Trelegy Ellipta at the same time each day, and not more than once in a 24-hour period. Other combination medications that may be used to treat COPD include: Other medications that may be used to treat COPD include: Note: Trelegy Ellipta and the alternative drugs listed here are meant to be used over time to control COPD symptoms. Results showed a 25% reduction in the annual rate of flare-ups vs. Anoro, and a 15% reduction in the annual rate of flare-ups vs. Breo. It should be taken every day to treat your condition over a long-term period. The Trelegy Ellipta patient assistance program can provide your medication for free. What are some alternatives for Trelegy Ellipta? One study showed that FEV1 in people who took Trelegy Ellipta was 59 mL higher than it was in people who took fluticasone and vilanterol. They may have alternate medications that dont interact with Trelegy Ellipta. Talk to your provider right away if you experience blurry vision, eye discomfort, or other changes in their vision after using Trelegy Ellipta. * This is a partial list of mild side effects from Trelegy Ellipta. This medication is taken as one inhalation (puff) of Trelegy Ellipta once each day. In September 2017, the FDA approved Trelegy Ellipta for the long-term maintenance of chronic obstructive pulmonary disease (COPD). However, this doesnt mean that Trelegy Ellipta will be present in human breast milk. Its important to note that Trelegy Ellipta is meant to be used over time to control COPD symptoms. It also helps keep the drug from harming the environment. If you think youve taken too much of this drug, call your doctor. Breo Ellipta contains two active drug ingredients: fluticasone and vilanterol. The drug was studied and shown to be safe and effective for long-term use in people with either COPD or asthma. Copyright 1996-2023 Drugs.com. diarrhea. Below are examples of these side effects. So if you have a severe milk protein allergy, you may have an allergic reaction to this medication. Medically reviewed by Leigh Ann Anderson, PharmD. Accessed Oct. 4, 2022 at, Phase III CAPTAIN study of Trelegy Ellipta in patients with asthma meets primary endpoint. Other combination medications that may be used to treat asthma include: Other medications that may be used to treat asthma include: Note: Trelegy Ellipta and the alternative drugs listed here are meant to be used over time to control asthma symptoms. fluticasone furoate/umeclidinium/vilanterol, chronic obstructive pulmonary disease (COPD), full product information for Trelegy Ellipta here. If you develop symptoms of thrush, be sure to see your doctor. Trelegy Ellipta hasnt been studied in pregnant animals either. A steroid medication's half-life determines how long it circulates in your body. Trelegy Ellipta is approved in two strengths for use in asthma: 100/62.5/25 mcg and 200/62.5/25 mcg, while only the 100/62.5/25mcg strength is approved in COPD. The drug can also make a certain type of glaucoma called narrow-angle glaucoma worse. Step 1: Prepare a dose Wait to open the cover until you are ready to take your dose. Accessed Oct. 4, 2022 at. It is used for long-term maintenance treatment of these conditions. There is an additional strength for asthma only (not for COPD) which is fluticasone furoate 200 mcg / umeclidinium 62.5 mcg / vilanterol 25mcg. Symbicort comes as a metered dose inhaler. Trelegy Ellipta is also contraindicated in people with allergies to any of the ingredients in the medication, including fluticasone furoate, umeclidinium, vilanterol, lactose monohydrate, and magnesium stearate. loss of appetite. The inhaler isnt reusable, and you cant refill it. If you do not have a fast-acting inhaler, call your doctor for a prescription. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Trelegy Ellipta. This medication works mainly in your lungs and isnt absorbed well into your body. Trelegy Ellipta contains three active drug ingredients: fluticasone, umeclidinium, and vilanterol. The following information is provided for clinicians and other healthcare professionals. So if youre taking Spiriva, youll need to stop using it before you start Trelegy Ellipta treatment. The drug comes as an inhaler, Chronic obstructive pulmonary disease (COPD) is an umbrella term for conditions that cause airflow and breathing difficulties. With emphysema, your lungs are damaged and have trouble passing air in and out. Symbicort is also approved to treat asthma in children ages 6 years and older. If you miss a dose of Trelegy Ellipta, take it as soon as you remember. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (To learn more, see the Trelegy Ellipta side effects section above.). In clinical trials, Trelegy Ellipta was effective in treating COPD. Because it contains three medicines, it may be useful for those on a fixed-dose combination of fluticasone / vilanterol (Breo Ellipta) who need added bronchodilation, or those who are already using Breo Ellipta and Incruse Ellipta (umeclidinium) as 2 separate medicines. Trelegy Ellipta Information for Consumers, Trelegy Ellipta Information for Healthcare Professionals. Revised 5/2022. Call your doctor for medical advice about side effects, precautions or warnings. It can improve symptoms of COPD for better breathing and to reduce the number of flare-ups (the worsening of your COPD symptoms). Trelegy Ellipta combines three medicines to improve lung function: fluticasone, a corticosteroid; vilanterol, a long-acting beta-agonist (LABA); and umeclidinium, an anticholinergic. The word "Ellipta" refers to the specific type of dry powder inhaler that contains the drug. They may suggest other medications. Taking too much umeclidinium isnt likely to cause you any serious side effects. It reaches steady state within 14 days of daily dosing. Improvements in lung function have also been seen when Trelegy was compared to Symbicort Turbuhaler in 24-week studies or with Symbicort plus Spiriva in 12 week studies. Trelegy Ellipta contains three active drug ingredients: fluticasone furoate, umeclidinium, and vilanterol. Trelegy Ellipta is a combination medication. There were no overdoses reported in people who took Trelegy Ellipta in clinical studies. Speak to your doctor or pharmacist about how drug interactions should be managed. The medication is in a powder form, and youll inhale it into your lungs as you take one deep breath. It is not known if this medicine is safe and effective in children younger than 18 years of age. Ask your doctor or pharmacist if you do not understand these instructions. The following medications are antimicrobials that can interact with Trelegy Ellipta: If you take any antimicrobial medications, especially the ones in the list above, talk with your doctor. COPD is a long-term disease in which the airways and air sacs inside the lungs become damaged or blocked, leading to difficulty breathing. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Research Triangle Park, NC: GlaxoSmithKline. Both Trelegy Ellipta and Symbicort are used in adults for the long-term treatment of: However, Symbicort is approved as a maintenance treatment for asthma only when: In addition to being approved for use in adults with asthma, Symbicort is also approved to treat asthma in children ages 6 years and older.